What’s Wrong with Non-regulated Interventions & Trials?

The following article (written by Rafeal Dal-Re, Michael Bracken & John Ioannidis in the BMJ) is a timely reminder to authors, journalists and consumers about the pros and cons of non-regulated interventions and trials. Efforts to promote the availability of data from clinical trials have been led predominantly by regulators (EMA, 2014) or drug companies… Read More


Cardiovascular Risk Factors, Type 2 Diabetes & Egg Consumption

Research Paper Title The Effect of a High-egg Diet on Cardiovascular Risk Factors in People with Type 2 Diabetes: The Diabetes and Egg (DIABEGG) study – A 3-mo Randomized Controlled Trial. Background Previously published research that examined the effects of high egg consumption in people with type 2 diabetes (T2D) produced conflicting results leading to… Read More

School-based Education Programmes to Reduce Salt Intake: Do They Work?

Research Paper Title School based education programme to reduce salt intake in children and their families (School-EduSalt): cluster randomised controlled trial. Objective To determine whether an education programme targeted at schoolchildren could lower salt intake in children and their families. Design Cluster randomised controlled trial, with schools randomly assigned to either the intervention or control… Read More

Fat Chance of Advice!

Government advice may be a fat lot of good. A controversial study claims dietary guidelines issued on fat intake to reduce the risk of heart disease were not supported by evidence from clinical trials. In 1977, the US government said fat intake should make up no more than 30% of an individual’s diet, and saturated… Read More

Is Vitamin D3 a Promising Intervention for the Prevention of URTI?

Research Paper Title Vitamin D3 and Gargling for the Prevention of Upper Respiratory Tract Infections: A Randomized Controlled Trial. Background The researchers undertook a 2X2 factorial, randomised controlled trial (RCT) to assess whether vitamin D3supplementation (10,000 international units per week) versus placebo and gargling versus no gargling could prevent viral, clinical upper respiratory tract infection (URTI)… Read More

Vitamin D & Risk of Cause Specific Death

Research Paper Title Vitamin D and Risk of Cause Specific Death: Systematic Review and Meta-analysis of Observational Cohort and Randomised Intervention Studies. Obejctive To evaluate the extent to which circulating biomarker and supplements of vitamin D are associated with mortality from cardiovascular, cancer, or other conditions, under various circumstances. Design Systematic review and meta-analysis of… Read More

Tennis Elbow: TENS & Primary Care Management

Research Paper Title Transcutaneous Electrical Nerve Stimulation as Adjunct to Primary Care Management for Tennis Elbow: Pragmatic Randomised Controlled Trial (TATE Trial). Study Question Can transcutaneous electrical nerve stimulation (TENS), as a patient controlled adjunct to primary care management for tennis elbow, provide superior pain relief to primary care management alone? Summary Answer TENS conferred… Read More