What is Muscle Hypertrophy

Introduction Muscle hypertrophy or muscle building involves a hypertrophy or increase in size of skeletal muscle through a growth in size of its component cells. Two factors contribute to hypertrophy: sarcoplasmic hypertrophy, which focuses more on increased muscle glycogen storage; and myofibrillar hypertrophy, which focuses more on increased myofibril size. It is the primary focus… Read More

What is Muscle Atrophy?

Introduction Muscle atrophy is the loss of skeletal muscle mass. It can be caused by immobility, ageing, malnutrition, medications, or a wide range of injuries or diseases that impact the musculoskeletal or nervous system. Muscle atrophy leads to muscle weakness and causes disability. Disuse causes rapid muscle atrophy and often occurs during injury or illness… Read More

Mice: Linking Aerobic Exercise & Heart Failure

Research Paper Title Aerobic exercise protects against pressure overload-induced cardiac dysfunction and hypertrophy via β3-AR-nNOS-NO activation. Background Aerobic exercise confers sustainable protection against cardiac hypertrophy and heart failure (HF). Nitric oxide synthase (NOS) and nitric oxide (NO) are known to play an important role in exercise-mediated cardioprotection, but the mechanism of NOS/NO stimulation during exercise… Read More

Young & Old: Vitamin D, Resistance Training & Skeletal Muscle

Research Paper Title Does vitamin-D Intake during Resistance Training Improve the Skeletal Muscle Hypertrophic and Strength Response in Young and Elderly Men? – A Randomised Controlled Trial. Introduction Recent studies have shown that vitamin-D intake can improve skeletal muscle function and strength in frail vitamin-D insufficient individuals. The researchers investigated whether vitamin-D intake can improve… Read More

Research: Muscles; Big, Bigger & Not So Big!

Research Paper Title Differential Response of Skeletal Muscles to mTORC1 signaling during Atrophy and Hypertrophy. Background Skeletal muscle mass is determined by the balance between protein synthesis and degradation. Mammalian target of rapamycin complex 1 (mTORC1) is a master regulator of protein translation and has been implicated in the control of muscle mass. Inactivation of… Read More