An editorial from the Annals of Internal Medicine in the April 2015 edition: In 2003, mutations in the gene encoding the enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9) were identified as genetic causes for familial hypercholesterolemia (1). Investigations soon showed that PCSK9 was a key regulator of low-density lipoprotein (LDL) cholesterol metabolism that promoted the… Read More
Research Paper Title Association Between Dietary Whole Grain Intake and Risk of Mortality Two Large Prospective Studies in US Men and Women. Importance Higher intake of whole grains has been associated with a lower risk of major chronic diseases, such as type 2 diabetes mellitus and cardiovascular disease (CVD), although limited prospective evidence exists regarding whole… Read More
Raised blood sugar, blood pressure (BP) and blood cholesterol are risk factors often clustered together. However, two new studies from Asia try to disentangle their interactions. In the Chinese population, blood glucose level within prediabetic range is significantly associated with elevated risks for diabetes mellitus after multi-variable adjustment, but only when it is concurrent with… Read More
Background Sauna bathing is a health habit associated with better haemodynamic function; however, the association of sauna bathing with cardiovascular and all-cause mortality is not known. The purpose of this study was to investigate the association of frequency and duration of sauna bathing with the risk of sudden cardiac death (SCD), fatal coronary heart disease… Read More
Research Paper Title Sleep Duration and Total and Cause-Specific Mortality in a Large US Cohort: Interrelationships With Physical Activity, Sedentary Behavior, and Body Mass Index. Background Both short and long durations of sleep are associated with higher mortality, but little is known about the interrelationship between sleep and other modifiable factors in relation to mortality.… Read More
Research Paper Title Sulfonylurea Use and Incident Cardiovascular Disease Among Patients With Type 2 Diabetes: Prospective Cohort Study Among Women. Background Evidence is inconsistent for the association between sulfonylurea use and risk of cardiovascular disease among patients with diabetes. The researchers aimed to prospectively evaluate this association using the Nurses’ Health Study (NHS), a well-established… Read More
Research Paper Title Compartmental Neck Fat Accumulation and its Relationship to Cardiovascular Risk and Metabolic Syndrome. Background Neck circumference is a predictor of cardiovascular disease (CVD) risk. However, detailed assessment of neck fat has not been explored, and the contribution from individual neck fat compartments to CVD risk is unknown. Objective The objective was to… Read More
Boot Camp & Military Fitness Institute 