PCSK9 and LDL Cholesterol: Any Good?

An editorial from the Annals of Internal Medicine in the April 2015 edition: In 2003, mutations in the gene encoding the enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9) were identified as genetic causes for familial hypercholesterolemia (1). Investigations soon showed that PCSK9 was a key regulator of low-density lipoprotein (LDL) cholesterol metabolism that promoted the… Read More