Ferritin Levels: Iron Deficiency & Overload

Research Paper Title Interpreting Raised Serum Ferritin Levels. Abstract A 60 year old businessman attended his general practitioner after an insurance medical examination at which abnormal liver function tests had been noted (alanine aminotransferase 70 IU/L (normal range 10-40 IU/L) and γ-glutamyltransferase 120 IU/L (normal range 0-37 IU/L)). He was otherwise fit and well and not taking regular medication. His… Read More

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Obesity & Non-Alcoholic Fatty Liver Disease

Non-alcoholic fatty liver disease (NAFLD) is now more common than alcoholic liver disease owing to the rapid rise in the prevalence of obesity (Marchesini et al., 2008), and NAFLD is the most common cause of abnormal liver function tests (Clark et al., 2011). Its prevalence worldwide is thought to be approximately 20% in the general population… Read More

What is the Link between Adiposity & Cardiometabolic Disease?

A genetic predisposition to obesity is randomly allocated, and mendelian randomisation studies exploit this natural experiment to find out if well established associations between obesity and disease are likely to be causal. The latest study used a genetic variation that increases body mass index (BMI) by 0.36 unit per allele. In analyses pooling 36 observational… Read More