by Andrew Marshall

The FTO Gene: What is the Effect on Adiposity, Energy Expenditure & Food Intake?

Research Paper Title The ‘Fat Mass and Obesity Related’ (FTO) Gene: Mechanisms of Impact on Obesity and Energy Balance. Abstract A cluster of single nucleotide polymorphisms (SNPs) in the first intron of the fat mass and obesity related (FTO) gene were the first common variants discovered to be associated with body mass index (BMI) and body fatness. This review summarises… Read More

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by Andrew Marshall

What is the Link between Adiposity & Cardiometabolic Disease?

A genetic predisposition to obesity is randomly allocated, and mendelian randomisation studies exploit this natural experiment to find out if well established associations between obesity and disease are likely to be causal. The latest study used a genetic variation that increases body mass index (BMI) by 0.36 unit per allele. In analyses pooling 36 observational… Read More