What is Exercise-Induced Euphoria?

Introduction Continuous exercise can produce a transient state of euphoria – an emotional state involving the experience of pleasure and feelings of profound contentment, elation, and well-being – which is colloquially known as a “runner’s high” in distance running or a “rower’s high” in rowing. Outline The runner’s high is a transient state of euphoria… Read More

What is Exercise-Induced Anaphylaxis?

Introduction Exercise-induced anaphylaxis (EIA, EIAn, EIAs) is a rare condition in which anaphylaxis, a serious or life-threatening allergic response, is brought on by physical activity. Approximately 5-15% of all reported cases of anaphylaxis are thought to be exercise-induced. The exact proportion of the population with EIA is unknown, but a 2001 study of 76,229 Japanese… Read More

An Overview of Stair Climbing

Introduction Stair climbing is the climbing of a flight of stairs. It is often described as a “low-impact” exercise, often for people who have recently started trying to get in shape. A common exhortation in health pop culture is “Take the stairs, not the elevator”. Energy Expenditure In one study (Teh and Aziz, 2002) based… Read More

What is Post-Exertional Malaise?

Introduction Post-exertional malaise (PEM), sometimes referred to as post-exertional symptom exacerbation (PESE) or post-exertional neuroimmune exhaustion (PENE), is a worsening of symptoms that occurs after minimal exertion. It is the hallmark symptom of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) and common in long COVID and fibromyalgia. PEM is often severe enough to be disabling, and is… Read More

What is Exercise Intolerance?

Introduction Exercise intolerance is a condition of inability or decreased ability to perform physical exercise at the normally expected level or duration for people of that age, size, sex, and muscle mass. It also includes experiences of unusually severe post-exercise pain, fatigue, nausea, vomiting or other negative effects. Exercise intolerance is not a disease or… Read More

What is Metabolic Myopathy?

Introduction Metabolic myopathies are myopathies that result from defects in biochemical metabolism that primarily affect muscle. They are generally genetic defects (inborn errors of metabolism) that interfere with the ability to create energy, causing a low adenosine triphosphate (ATP) reservoir within the muscle cell. At the cellular level, metabolic myopathies lack some kind of enzyme… Read More

What is the Endurance Running Hypothesis?

Introduction The endurance running hypothesis is a series of conjectures which presume humans evolved anatomical and physiological adaptations to run long distances and, more strongly, that “running is the only known behavior that would account for the different body plans in Homo as opposed to apes or australopithecines”. The hypothesis posits a significant role of… Read More