What is Exercise Intolerance?

Introduction Exercise intolerance is a condition of inability or decreased ability to perform physical exercise at the normally expected level or duration for people of that age, size, sex, and muscle mass. It also includes experiences of unusually severe post-exercise pain, fatigue, nausea, vomiting or other negative effects. Exercise intolerance is not a disease or… Read More

What is Metabolic Myopathy?

Introduction Metabolic myopathies are myopathies that result from defects in biochemical metabolism that primarily affect muscle. They are generally genetic defects (inborn errors of metabolism) that interfere with the ability to create energy, causing a low adenosine triphosphate (ATP) reservoir within the muscle cell. At the cellular level, metabolic myopathies lack some kind of enzyme… Read More

What is the Endurance Running Hypothesis?

Introduction The endurance running hypothesis is a series of conjectures which presume humans evolved anatomical and physiological adaptations to run long distances and, more strongly, that “running is the only known behavior that would account for the different body plans in Homo as opposed to apes or australopithecines”. The hypothesis posits a significant role of… Read More

An Overview of Ventricular Remodelling

Introduction In cardiology, ventricular remodelling (or cardiac remodelling) refers to changes in the size, shape, structure, and function of the heart. This can happen as a result of exercise (physiological remodelling) or after injury to the heart muscle (pathological remodelling). The injury is typically due to acute myocardial infarction (usually transmural or ST segment elevation… Read More

An Overview of Muscle Weakness

Introduction Muscle weakness is a lack of muscle strength (not to be confused with muscle fatigue). Its causes are many and can be divided into conditions that have either true or perceived muscle weakness. True muscle weakness is a primary symptom of a variety of skeletal muscle diseases, including muscular dystrophy and inflammatory myopathy. It… Read More

An Overview of Muscle Fatigue

Introduction Muscle fatigue is when muscles that were initially generating a normal amount of force, then experience a declining ability to generate force. It can be a result of vigorous exercise, but abnormal fatigue may be caused by barriers to or interference with the different stages of muscle contraction. There are two main causes of… Read More

A National Emergency: The Rising Rates of Veteran Suicide and Overdose

Introduction Veteran suicide and overdose rates continue to rise, creating an urgent crisis that demands our immediate attention. According to research from America’s Warrior Partnership the actual daily number of Veterans who take their own lives may be close to 44 when factoring in unreported cases and overdose-related deaths. These alarming statistics prove the need… Read More