What are the Risk Factors for Acute Respiratory Distress Syndrome (ARDS) in Combat Casualty Care?

Research Paper Title

Incidence, risk factors, and mortality associated with acute respiratory distress syndrome in combat casualty care.

Background

The overall incidence and mortality of acute respiratory distress syndrome (ARDS) in civilian trauma settings have decreased over the past four decades; however, the epidemiology and impact of ARDS on modern combat casualty care are unknown. We sought to determine the incidence, risk factors, resource utilisation, and mortality associated with ARDS in current combat casualty care.

Methods

This was a retrospective review of mechanically ventilated US combat casualties within the Department of Defence Trauma Registry (formerly the Joint Theatre Trauma Registry) during Operation Iraqi Freedom/Enduring Freedom (October 2001 to August 2008) for ARDS development, resource utilisation, and mortality.

Results

Of 18,329 US Department of Defence Trauma Registry encounters, 4,679 (25.5%) required mechanical ventilation; ARDS was identified in 156 encounters (3.3%). On multivariate logistic regression, ARDS was independently associated with female sex (odds ratio [OR], 2.62; 95% confidence interval [CI], 1.21-5.71; p = 0.02), higher military-specific Injury Severity Score (Mil ISS) (OR, 4.18; 95% CI, 2.61-6.71; p < 0.001 for Mil ISS ≥25 vs. <15), hypotension (admission systolic blood pressure <90 vs. ≥90 mm Hg; OR, 1.76; 95% CI, 1.07-2.88; p = 0.03), and tachycardia (admission heart rate ≥90 vs. <90 beats per minute; OR, 1.53; 95% CI, 1.06-2.22; p = 0.02). Explosion injury was not associated with increased risk of ARDS. Critical care resource utilisation was significantly higher in ARDS patients as was all-cause hospital mortality (ARDS vs. no ARDS, 12.8% vs. 5.9%; p = 0.002). After adjustment for age, sex, injury severity, injury mechanism, Mil ISS, hypotension, tachycardia, and admission Glasgow Coma Scale score, ARDS remained an independent risk factor for death (OR, 1.99; 95% CI, 1.12-3.52; p = 0.02).

Conclusions

In this large cohort of modern combat casualties, ARDS risk factors included female sex, higher injury severity, hypotension, and tachycardia, but not explosion injury. Patients with ARDS also required more medical resources and were at greater risk of death compared with patients without ARDS. Thus, ARDS remains a significant complication in current combat casualty care.

Reference

Park, P.K., Cannon, J.W., Ye, W., Blackbourne, L.H., Holcomb, J.B., Beninati, W. & Napolitano, L.M. (2016) Incidence, Risk Factors, and Mortality Associated with Acute Respiratory Distress Syndrome in Combat Casualty Care. The Journal of Trauma and Acute Care Surgery. 2016 Nov;81(5 Suppl 2 Proceedings of the 2015 Military Health System Research Symposium):S150-S156.

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