Coffee Consumption & Mortality

Research Paper Title

Coffee Consumption and Mortality From All Causes, Cardiovascular Disease, and Cancer: A Dose-Response Meta-Analysis.

Background

Several studies have analysed the relationship between coffee consumption and mortality, but the shape of the association remains unclear.

Methods

The researchers conducted a dose-response meta-analysis of prospective studies to examine the dose-response associations between coffee consumption and mortality from all causes, cardiovascular disease (CVD), and all cancers. Pertinent studies, published between 1966 and 2013, were identified by searching PubMed and by reviewing the reference lists of the selected articles. Prospective studies in which investigators reported relative risks of mortality from all causes, CVD, and all cancers for 3 or more categories of coffee consumption were eligible.

Results

Results from individual studies were pooled using a random-effects model. Twenty-one prospective studies, with 121,915 deaths and 997,464 participants, met the inclusion criteria. There was strong evidence of nonlinear associations between coffee consumption and mortality for all causes and CVD (P for nonlinearity < 0.001). The largest risk reductions were observed for 4 cups/day for all-cause mortality (16%, 95% confidence interval: 13, 18) and 3 cups/day for CVD mortality (21%, 95% confidence interval: 16, 26). Coffee consumption was not associated with cancer mortality.

Conclusions

Findings from this meta-analysis indicate that coffee consumption is inversely associated with all-cause and CVD mortality.

Reference

Crippa, A., Discacciati, A., Larsson, S.C., Wolk, A. & Orsini, N. (2014) Coffee Consumption and Mortality From All Causes, Cardiovascular Disease, and Cancer: A Dose-Response Meta-Analysis. American Journal of Epidemiology. First published online: August 24, 2014. doi: 10.1093/aje/kwu194

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