The Role of BP Lowering: With & Without Chronic Kidney Disease

Research Paper Title

Blood Pressure Lowering and Major Cardiovascular Events in People with and without Chronic Kidney Disease: Meta-analysis of Randomised Controlled Trials.

Study Question

Do the effects of lowering blood pressure on the risk of cardiovascular events differ between people with and without chronic kidney disease?

Summary Answer

The proportional reductions in risk of cardiovascular complications with lowered blood pressure are similar in people with and without chronic kidney disease, but people with kidney disease gain larger absolute benefits because their baseline risk is higher.

What is Known and What This Paper Adds

Blood pressure lowering is an effective strategy for preventing cardiovascular events, and this study shows that this is also true among people with chronic kidney disease. There is, however, little evidence to support the preferential choice of particular drug classes for the prevention of cardiovascular events in people with chronic kidney disease.


BMJ 2013;347:f5680


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