Research Paper Title

Military Tuberculosis in a Young Woman with Haemophagocytic Syndrome: A Case Report and Literature Review.

Abstract

The researchers report a rare case of miliary tuberculosis-associated haemophagocytic syndrome (HPS) complicated with respiratory failure.

A 19-year-old Japanese woman with a fever, general malaise, and chest radiograph abnormalities was referred to our hospital.

After admission, she developed respiratory failure with pancytopenia. A histological examination of lung and bone marrow biopsy samples revealed noncaseating granulomas without evidence of acid-fast bacilli or lymphoma.

In addition, a bone marrow biopsy showed marked histiocyte hyperplasia with haemophagocytosis, and a bronchoalveolar lavage fluid culture grew Mycobacterium tuberculosis.

Therefore, a diagnosis of miliary tuberculosis-associated HPS was made. The patient was successfully treated with antituberculous therapy.

Reference

Asaji, M., Tobino, K., Murakami, K., Goto, Y., Sueyasu, T., Nishizawa, S., Yoshimine, K., Munechika, M., Ko, Y., Yoshimatsu, Y., Tsuruno, K., Ide, H., Miyajima, H. & Ebi, N. (2017) Military Tuberculosis in a Young Woman with Hemophagocytic Syndrome: A Case Report and Literature Review. Internal Medicine. 56(12): 1591–1596. doi: 10.2169/internalmedicine.56.8025.